The decisive step in ...

The decisive step in evolution, the first step toward macroevolution, the step from one species to another, requires another evolutionary method than that of sheer accumulation of micromutations.
 Richard Goldschmidt

Quotes from the same author

It is good to keep in mind ... that nobody has ever succeeded in producing even one new species by the accumulation of micromutations. Darwin's theory of natural selection has never had any proof, yet it has been universally accepted.
 Richard Goldschmidt