The scientific theorist is not to be envied. For Nature, or more precisely experiment, is an exorable and not very friendly judge of his work. It never says "yes" to a theory. In the most favorable cases it says "Maybe," and in the great majority of cases simply "No." If an experiment agrees with a theory it means for the latter "Maybe," and if it does not agree it means "No." Probably every theory will some day experience its "No" - most theories, soon after conception.
