The essential fact is that all the pictures which science now draws of nature, and which alone seem capable of according with observational facts, are mathematical pictures.
Sciences usually advances by a succession of small steps, through a fog in which even the most keen-sighted explorer can seldom see more than a few paces ahead. Occasionally the fog lifts, an eminence is gained, and a wider stretch of territory can be surveyed-sometimes with startling results. A whole science may then seem to undergo a kaleidoscopic rearrangement, fragments of knowledge sometimes being found to fit together in a hitherto unsuspected manner. Sometimes the shock of readjustment may spread to other sciences; sometimes it may divert the whole current of human thought.
In real science a hypothesis can never be proved true...A science which confines itself to correlating phenomena can never learn anything about the reality underlying the phenomena, while a science which goes further than this and introduces hypotheses about reality, can never acquire certain knowledge of a positive kind about reality; in whatever way we proceed, this is forever denied us.