I basically drew my own family. My father's name is Homer. My mother's name is Margaret. I have a sister Lisa and another sister Maggie, so I drew all of them. I was going to name the main character Matt, but I didn't think it would go over well in a pitch meeting, so I changed the name to Bart.
'The Simpsons' from the very beginning was based on our memories of brash '60s sitcoms - you had a main title theme that was bombastic and grabbed your attention - and when you look at TV shows of the 1970s and '80s, things got very mild and toned down and... obsequious.
I think people who work in comedy and humor are hesitant to analyze it too much, because you feel like if you take it apart, you'll break it and not be able to put it back together again.