In real science a hypothesis ...

In real science a hypothesis can never be proved true...A science which confines itself to correlating phenomena can never learn anything about the reality underlying the phenomena, while a science which goes further than this and introduces hypotheses about reality, can never acquire certain knowledge of a positive kind about reality; in whatever way we proceed, this is forever denied us.
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 James Jeans

Quotes from the same author

The essential fact is that all the pictures which science now draws of nature, and which alone seem capable of according with observational facts, are mathematical pictures.
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 James Jeans
Science should leave off making pronouncements: the river of knowledge has too often turned back on itself.
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 James Jeans
Sciences usually advances by a succession of small steps, through a fog in which even the most keen-sighted explorer can seldom see more than a few paces ahead. Occasionally the fog lifts, an eminence is gained, and a wider stretch of territory can be surveyed-sometimes with startling results. A whole science may then seem to undergo a kaleidoscopic rearrangement, fragments of knowledge sometimes being found to fit together in a hitherto unsuspected manner. Sometimes the shock of readjustment may spread to other sciences; sometimes it may divert the whole current of human thought.
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 James Jeans
Put three grains of sand inside a vast cathedral, and the cathedral will be more closely packed with sand than space is with stars.
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 James Jeans