Every heat engineer knows he ...

Every heat engineer knows he can design his heat engine reliably and accurately on the foundation of the second law [of thermodynamics]. Run alongside one of the molecules, however, and ask it what it thinks of the second law. It will laugh at us. It never heard of the second law. It does what it wants. All the same, a collection of billions upon billions of such molecules obeys the second law with all the accuracy one could want
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 John Archibald Wheeler

Quotes from the same author

In order to more fully understand this reality, we must take into account other dimensions of a broader reality.
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 John Archibald Wheeler
Time, among all concepts in the world of physics, puts up the greatest resistance to being dethroned from ideal continuum to the world of the discrete, of information, of bits.... Of all obstacles to a thoroughly penetrating account of existence, none looms up more dismayingly than 'time.' Explain time? Not without explaining existence. Explain existence? Not without explaining time. To uncover the deep and hidden connection between time and existence ... is a task for the future.
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 John Archibald Wheeler
Spacetime tells matter how to move; matter tells spacetime how to curve.
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 John Archibald Wheeler